The plan has a total budget of 319 million USD and will be implemented across all 55 member states of the African Union. Of this amount, 265 million USD will be prioritized for direct outbreak response efforts in the DRC and Uganda, while 54 million USD will support preparedness activities, surveillance systems, and disease-control capacity-building in high-risk African countries.

In eastern DRC, the epicenter of the current Ebola outbreak, local authorities have stepped up sanitation and disease prevention measures. This outbreak is linked to the rare Bundibugyo strain of the Ebola virus, for which there is no approved vaccine available.