The November 6-17 trip will be especially significant to Peru, where Pope Leo spent decades as a missionary and bishop. He served as bishop of Chiclayo from 2015 to 2023 and holds Peruvian citizenship. His return to Chiclayo, the diocese he led before his election, will be one of the key moments of the trip.

Peruvian President Keiko Fujimori said His Holiness's arrival will be "a moment of coming together for our faith and a message of hope for our country."

Peru’s Foreign Affairs Minister Carlos Espa said his government is preparing contingency plans to ensure that the visit proceeds smoothly.